At CB1 Medical, we often get questions about HHC (hexahydrocannabinol) and its effects.
With claims online that it is a “legal THC alternative,” it’s important to separate fact from fiction, especially under UK law. This guide explains what HHC is, how it is made, what it does in the body, and why it is not a safe or legal substitute for prescribed medical cannabis.
HHC is a semi-synthetic cannabinoid, meaning it does not occur naturally in usable amounts in the cannabis plant. Structurally similar to THC, small chemical differences change its potency, duration, and how the body processes it.
HHC appeared in scientific literature in the 1940s but only reached commercial markets around 2021, appearing in vapes, edibles, and other unregulated products. Despite marketing claims, HHC is illegal in the UK and is not licensed for medical use.
There are two main forms of HHC:
Most products contain a mixture of both forms, often without accurate labelling, so effects are unpredictable. By contrast, THC and CBD prescribed through UK clinics like CB1 Medical are medically tested, regulated, and delivered with precise dosing instructions.
HHC is produced in a lab using a chemical process called hydrogenation. Typically, manufacturers start with CBD extracted from hemp, then alter its structure using heat, pressure, and chemical solvents to produce a THC-like compound.
Unlike medical cannabis, which is directly plant-derived, HHC is synthetic and applied to vapes, edibles, or “HHC flower” to mimic cannabis.
There is currently no clinical research on HHC in humans. Available information comes from anecdotal reports, online forums, and user reviews. Reported effects include:
Because HHC is unregulated and inconsistently dosed, its effects are unpredictable.

HHC safety is unknown. There are no long-term studies, no clinical guidelines, and no product standards. Risks include:
Unlike medical cannabis prescribed by regulated UK clinics, HHC has no oversight or quality control.
Despite being illegal under the Psychoactive Substances Act 2016, HHC products are still available online or in shops, including:
All are lab-synthesised, not naturally extracted from cannabis. Labels are often unreliable, and product contents can vary widely.
HHC has no place in legitimate UK medical cannabis treatment. It is not prescribed, not clinically tested, and not regulated.
Prescribed medical cannabis from regulated clinics is GMP-certified, clinically monitored, and legally compliant. Every patient receives care that is evidence-based, personalised, and safely prescribed by UK-licensed specialists.

Does HHC show up on a drug test?
Most tests screen for THC. Because HHC is similar to THC, it may trigger a positive result.
Can you build a tolerance to HHC?
No formal research exists, but it acts on the same receptors as THC, so tolerance could develop.
What is HHC-O, and is it legal in the UK?
HHC-O is another lab-made variant of HHC. Like HHC, it is illegal, unregulated, and not prescribed.
HHC is illegal, unregulated, and unpredictable in the UK. It is not a safe or reliable substitute for medical cannabis.
At CB1 Medical, we provide patients with legally prescribed, clinically monitored cannabis products, ensuring quality, safety, and therapeutic oversight.
If you are considering medical cannabis in the UK, always seek advice from a specialist clinic rather than experimenting with unregulated HHC products.
Try our free Eligibility Checker to see if it may be right for you.